NEWS

Drug likely to change practice for patients with recurrent disease.
August 28

NIH offers $14.5 million to improve technology.
August 28

Study links variation in regulatory regions to colorectal tumors.
August 28

Data protection requirements could significantly hamper new studies, says ESMO.
August 21
 

Agency provides more details about how to obtain consent from patients enrolling in a clinical trial.
August 21

A tumor’s dominant clone may not be the most dangerous, offering clues for better targeted therapy.
August 14

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RESEARCH WATCH

The H3K27 demethylases UTX and JMJD3 have opposing roles in regulating NOTCH1-induced T-ALL growth.
August 28

The next-generation ALK inhibitor alectinib overcomes acquired crizotinib resistance in NSCLC.
August 28

PDAC cells surviving oncogene withdrawal are dependent on autophagy and mitochondrial metabolism.
August 21

PDGFA expression and PTEN loss are common genetic drivers of all non-GCIMP glioblastoma subtypes.
August 21

Chloroquine mediates tumor vessel normalization in an autophagy-independent manner.
August 21

NOTCH-regulated long noncoding RNAs (lncRNA) including LUNAR1 promote T-ALL cell growth.
August 14

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NOTED THIS WEEK

August 28, 2014

Santa Monica, CA–based Kite Pharma, Inc., announced that administration of KTE-C19, an anti-CD19 chimeric antigen receptor T-cell therapy, yielded an over-
all response rate of 92% in 13 evaluable patients with B-cell malignancies.
Eight patients in the phase I-IIa study experienced a complete remission and four experienced a partial remission. The findings were published in the Journal of Clinical Oncology.

Although it backs the battery-powered devices as a last resort to help smokers quit, the American Heart Association issued a policy statement urging government to more heavily regulate electronic cigarettes. E-cigarettes, as they are called, are less toxic than traditional cigarettes, but little evidence exists to support claims that they aid smoking cessation, and concerns abound that their candy and fruit flavorings will attract youth. A day later, the World Health Organization also called for increased regulation, such as bans on advertising, indoor use of e-cigarettes, and the sale of the devices to anyone under age 18, in advance of an international tobacco-control meeting scheduled for October.

Illumina announced that it will partner with AstraZeneca, Janssen Biotech, and Sanofi to develop a universal next-generation sequencing–based oncology test system to detect and measure multiple variants simultaneously. The system will be used for clinical trials of targeted cancer therapies with a goal of developing and commercializing a multigene panel to select the best therapy for each patient.

The Herbert Irving Comprehensive Cancer Center of Columbia University Medical Center and New York-Presbyterian Hospital earned an $18 million, 5-year cancer center support grant from the NCI. The grant renews the New York City center’s status as an NCI-designated comprehensive cancer center.

GE Healthcare Life Sciences announced that it will open its new U.S. head-
quarters in Marlborough, MA,
investing $21 million in a currently unoccupied site. Slated to open in the spring, the 160,000 square-foot facility will employ 500 workers and create 220 new jobs. The company’s global headquarters will remain in Amersham, UK.

According to the London, UK, research and consulting firm GlobalData, the market for drugs to treat B-cell non-Hodgkin lymphoma will experience moderate growth, from $4.59 billion in 2013 to $5.41 billion by 2018, across the United States, France, Italy, Germany, Spain, and the UK. The market will undergo a dramatic shift away from chemotherapeutics to targeted
B-cell receptor inhibitors such as ibrutinib (Imbruvica; Pharmacyclics and Janssen) and idelalisib (Zydelig; Gilead), the firm says.

The NIH is challenging science innovators to compete for prizes totaling up to $500,000 by developing new ways to track the health status of a single cell in complex tissue over time. The Follow that Cell Challenge seeks tools that would, for example, monitor a cell in the process of becoming cancerous or how a cell responds to treatment.

Having completed a 14-month engagement
at the Smithsonian’s National Museum of Natural History in Washington, DC, the exhibition “Genome: Unlocking Life’s Code” is on the move to San Diego, CA, for the first of eight planned stops throughout North America. A collabo-
ration between the museum and the National Human Genome Research Institute, part of the NIH, the exhibition’s eye-catching models and interactive displays that have already attracted 3 million visitors. It opens in San Diego on September 24.

Baseball pitching great Curt Schilling announced that he has been treated for an oral squamous cell carcinoma that he “unquestionably” believes was caused by decades of chewing tobacco use, saying he wished he “could go back and never have dipped.” Earlier this year, Hall of Famer Tony Gwynn died of salivary gland cancer, which he also attributed to chewing tobacco. Cancer prevention advocates say they hope Schilling’s and Gwynn’s experiences will discourage people, particularly young baseball fans, from using any type of tobacco.

RESEARCH WATCH